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[大脑单侧电刺激对大鼠听源性惊厥发作的影响]

[Effects of lateralized electric stimulation of the brain on audiogenic convulsive attack in rats].

作者信息

Konovalov V F, Otmakhova N A

出版信息

Biull Eksp Biol Med. 1989 Jul;108(7):17-8.

PMID:2804288
Abstract

The influence of lateralized and bilateral electrical stimulations of the rat's brain on the course of audiogenic convulsive fit was analyzed. It was found, that after operative application of electrodes to the animal's skull the strength of fit and audiogenic seizure susceptibility decreased in all experimental groups. At the same time the second group, in which the left hemisphere was stimulated, essentially differed from other groups. The occasions of omission of some stages of fit were not so frequent, there, and only in this group after electrostimulation fits increased in the form of arising of new stages. This allows us to propose a special role of the left hemisphere of rats in forming a complete convulsive fit. The described observations resemble those of human asymmetry.

摘要

分析了大鼠大脑单侧和双侧电刺激对听源性惊厥发作过程的影响。结果发现,在动物颅骨上手术植入电极后,所有实验组的惊厥发作强度和听源性癫痫易感性均降低。同时,刺激左半球的第二组与其他组有本质区别。在该组中,惊厥发作某些阶段遗漏的情况不那么频繁,而且只有在该组电刺激后,惊厥发作以出现新的阶段的形式增加。这使我们能够提出大鼠左半球在形成完整惊厥发作中具有特殊作用。所描述的观察结果类似于人类不对称性的观察结果。

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