Kuznetsov G D
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jan-Feb;48(1):143-52.
The temporal parameters of audiogenic seizures were compared in rats of different genetic strains (KM, Wistar, WAG/Rij, and GK). The probability of the origin of audiogenic fits was defined in each of the strains. It was found out that in Wistar, WAG/Rij, and GK rats the audiogenic fits developed as a double-wave pattern. In these strains the seizure intensity and their temporal parameters were the same but considerably differed from the intensive fits in KM rats, which developed as a one-wave pattern. The duration of the inhibitory pause between the first and the second wave in a double-wave fit was extremely stable, which could result from the spreading depression in one of the subcortical nuclei. Frequency spectra were compared of different kinds of stimuli applied for the audiogenic testing. Seizures were more easily provoked by the ultrasound signals with a complex structure. The resemblance is discussed between such signals and the natural communicative acoustic signals of rats as well as a possible role of emotional factor in the development of the audiogenic seizures.
比较了不同遗传品系（KM、Wistar、WAG/Rij和GK）大鼠听源性癫痫发作的时间参数。确定了每个品系听源性惊厥发作的起始概率。结果发现，在Wistar、WAG/Rij和GK大鼠中，听源性惊厥以双波模式发作。在这些品系中，惊厥强度及其时间参数相同，但与KM大鼠的强烈惊厥有很大差异，KM大鼠的惊厥以单波模式发作。双波惊厥中第一波和第二波之间抑制性停顿的持续时间极其稳定，这可能是由于皮层下核之一的扩散性抑制所致。比较了用于听源性测试的不同类型刺激的频谱。结构复杂的超声信号更容易诱发惊厥。讨论了此类信号与大鼠自然交流声信号之间的相似性，以及情绪因素在听源性惊厥发展中的可能作用。
