对格杜宁ABC环系的合成认识
Gaining Synthetic Appreciation for the Gedunin ABC Ring System.
作者信息
Pinkerton David M, Vanden Berg Timothy J, Bernhardt Paul V, Williams Craig M
机构信息
School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, 4072, Queensland, Australia.
出版信息
Chemistry. 2017 Feb 16;23(10):2282-2285. doi: 10.1002/chem.201605751. Epub 2017 Feb 1.
PMID:28042894
Abstract
Gedunin, first isolated in 1960, displays a remarkable range of biological activity, but has yet to receive dedicated synthetic attention from a ground up construction perspective. Presented herein is a successfully executed approach to the fully functionalized ABC ring system of this challengingly complex natural product.
摘要
格杜宁于1960年首次分离出来，具有广泛的生物活性，但从从头构建的角度来看，尚未受到专门的合成关注。本文介绍了一种成功实施的方法，用于构建这种极具挑战性的复杂天然产物的全功能化ABC环系统。
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