Centro de Investigação em Saúde e Ambiente, Escola Superior de Saúde, Instituto Politécnico do Porto, 4200-072 Porto, Portugal.
Bio4Life4You, 4460-170 Porto, Portugal.
Molecules. 2020 Jan 23;25(3):493. doi: 10.3390/molecules25030493.
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.
吉敦宁是几种楝科植物中存在的一种重要的柠檬苦素，主要存在于种子中。吉敦宁具有多种生物学活性，包括抗菌、杀虫、抗疟、抗过敏、抗炎、抗癌和神经保护作用。吉敦宁作为热休克蛋白（Hsp）抑制剂的发现，为其作为生物治疗剂的应用奠定了一个非常重要的里程碑。本研究是对迄今为止描述的吉敦宁的几种生物学活性、它对一些人类疾病的治疗效果以及这种天然化合物未来研究方向的批判性文献综述。
