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阻塞性睡眠呼吸暂停与哮喘。

Obstructive sleep apnea and asthma.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

出版信息

Asian Pac J Allergy Immunol. 2016 Dec;34(4):265-271. doi: 10.12932/AP0828.

Abstract

Both asthma and obstructive sleep apnea (OSA) are common conditions involving the adults and children population, and have significant impact on the healthcare system. For the last few decades a lot of data emerged in terms of the prevalence between asthma and OSA. The prevalence ranges from 38% up to as high as 70%. Based on the current concepts of bidirectional relationship of OSA and asthma, it is sensible to assume that treating one disorder will result in the other's better control and vice versa. This review will look into the pathogenesis of concomitant OSA and asthma and whether the first line OSA therapy will result in better control of asthma in patients with concomitant OSA. There is growing evidence that continuous positive airway pressure (CPAP) in adults and adenotonsillectomy in children which are recommended as first line treatment of OSA can improve their asthma symptoms. However, further confirmation is necessary with larger randomized control trials to further evaluate both conditions and the treatment effects.

摘要

哮喘和阻塞性睡眠呼吸暂停(OSA)都是常见的疾病,影响着成人和儿童群体,对医疗保健系统有重大影响。在过去几十年中,出现了大量关于哮喘和 OSA 之间患病率的数据。患病率范围从 38%到高达 70%。根据 OSA 和哮喘双向关系的现有概念,可以合理地假设治疗一种疾病将导致另一种疾病的更好控制,反之亦然。这篇综述将探讨同时患有 OSA 和哮喘的发病机制,以及一线 OSA 治疗是否会导致同时患有 OSA 的患者的哮喘得到更好的控制。越来越多的证据表明,成人推荐的一线治疗 OSA 的持续气道正压通气(CPAP)和儿童腺样体扁桃体切除术可以改善他们的哮喘症状。然而,需要更大的随机对照试验来进一步评估这两种情况和治疗效果。

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