Liu Ting, Qin He
Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Medicine (Baltimore). 2025 Apr 11;104(15):e41918. doi: 10.1097/MD.0000000000041918.
There is a close relationship between asthma and obstructive sleep apnea (OSA), and the mechanisms of these 2 diseases are overlapped. However, the relationship between OSA and allergic asthma remains to be analyzed through systematic review and meta-analysis.
A systematic search was conducted using Scopus, PubMed, ISI, Google Scholar, and Cochrane Library by utilizing the keywords Allergic asthma, Obstructive sleep apnea, and OSA. Hazard ratio, odds ratio (OR), and risk ratio with 95% confidence interval, fixed and Mantel-Haenszel methods were calculated. Statistical software Stata was used for the evaluation of this meta-analysis.
Finally, 19 articles were included in this study. The prevalence of OSA in allergic asthma patients was 35.25% (19.92%, 50.57%), which was statistically significant, and pooled analysis of ORs observed in individual studies showed that the odds of OSA prevalence were 2.24 (1.32, 3.12) (P < 0.001). Also, the prevalence of OSA risk in allergic asthma patients was 30.08% (19.73%, 40.43%), which was statistically significant, and pooled analysis of ORs observed in individual studies showed that the odds of OSA risk were 3.46 (2.96, 4.94) (P < 0.001).
The present meta-analysis showed that the prevalence of OSA as well as the OSA risk in patients with asthma were significantly higher compared with healthy people.
哮喘与阻塞性睡眠呼吸暂停（OSA）之间存在密切关系，这两种疾病的机制相互重叠。然而，OSA与过敏性哮喘之间的关系仍有待通过系统评价和荟萃分析进行剖析。
利用关键词“过敏性哮喘”“阻塞性睡眠呼吸暂停”和“OSA”，通过Scopus、PubMed、ISI、谷歌学术和Cochrane图书馆进行系统检索。计算风险比、比值比（OR）以及具有95%置信区间的风险比，采用固定效应模型和Mantel-Haenszel方法。使用统计软件Stata对该荟萃分析进行评估。
最终，本研究纳入了19篇文章。过敏性哮喘患者中OSA的患病率为35.25%（19.92%，50.57%），具有统计学意义，对各研究中观察到的OR进行汇总分析表明，OSA患病率的比值为2.24（1.32，3.12）（P<0.001）。此外，过敏性哮喘患者中OSA风险的患病率为30.08%（19.73%，40.43%），具有统计学意义，对各研究中观察到的OR进行汇总分析表明，OSA风险的比值为3.46（2.96，4.94）（P<0.001）。
本荟萃分析表明，与健康人相比，哮喘患者中OSA的患病率以及OSA风险显著更高。
