Sone Daichi, Watanabe Masako, Ota Miho, Kimura Yukio, Sugiyama Atsuhiko, Maekawa Tomoko, Okura Mariko, Enokizono Mikako, Imabayashi Etsuko, Sato Noriko, Matsuda Hiroshi
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan.
Department of Psychiatry, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
Epilepsy Res. 2017 Jan;129:95-100. doi: 10.1016/j.eplepsyres.2016.12.009. Epub 2016 Dec 14.
The aim of this study was to investigate interictal cerebral blood flow (CBF) distributions and graph theoretical networks in idiopathic generalized epilepsy (IGE) using arterial spin labeling (ASL) imaging and anatomical covariance methods of graph theoretical analysis.
We recruited 19 patients with IGE and 19 age-/gender-matched healthy controls. Their CBF images were obtained by pseudo-continuous ASL imaging and compared using statistical parametric mapping 8 software (SPM8) and Graph Analysis Toolbox (GAT).
The ASL imaging could detect interictal hypoperfusion in the thalamus, upper midbrain, and left cerebellum in IGE. Additionally, the graph theoretical analyses revealed characteristic findings of the CBF network of IGE, including significantly reduced resilience to attacks and changes of regional clustering especially in the bilateral temporo-occipital areas and lateral frontal lobes. There was no significance in the comparisons of network metrics.
These findings could contribute to a better understanding of the pathophysiology of IGE.
本研究旨在使用动脉自旋标记（ASL）成像和图论分析的解剖协方差方法，研究特发性全身性癫痫（IGE）发作间期的脑血流（CBF）分布和图论网络。
我们招募了19例IGE患者和19名年龄及性别匹配的健康对照者。通过伪连续ASL成像获得他们的CBF图像，并使用统计参数映射8软件（SPM8）和图分析工具箱（GAT）进行比较。
ASL成像可检测到IGE患者丘脑、中脑上部和左侧小脑的发作间期灌注不足。此外，图论分析揭示了IGE的CBF网络的特征性发现，包括对发作的弹性显著降低以及区域聚类的变化，尤其是在双侧颞枕叶区域和额叶外侧。网络指标的比较无显著性差异。
这些发现有助于更好地理解IGE的病理生理学。
