Kretschmer Alexander, Buchner Alexander, Leitl Benedikt, Grabbert Markus, Sommer Anne, Khoder Wael, Gozzi Christian, Stief Christian G, Bauer Ricarda M
Department of Urology, Ludwig-Maximilians-University, Munich, Germany.
Department of Urological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.
Int Neurourol J. 2016 Dec;20(4):335-341. doi: 10.5213/inj.1632648.324. Epub 2016 Dec 26.
To evaluate long-term outcomes of AdVance and AdVanceXP male slings in patients with persistent stress urinary incontinence (SUI) after transurethral resection of the prostate (TURP).
A total of 18 consecutive patients received AdVance (n=14) or AdVanceXP (n=4) male sling implantation between 2007 and 2013. Continence was determined by pad use, 24-hour pad testing and validated questionnaires (International Consultation on Incontinence Questionnaire Short Form, ICIQ-SF). Quality of life was evaluated by International Quality of Life (IQoL) score. Patient satisfaction was measured with patient's global impression of improvement score. Cure was defined as 0-5 g in the 24-hour pad test. Statistical analysis included Fisher exact and Wilcoxon test (P<0.05).
Follow-up was available for 15 patients who underwent further analysis. After a median follow-up of 70 months (range, 18-83 months), mean daily pad usage was 1.8±2.1 pads (P=0.015 vs. baseline level). Mean IQoL score was 66.4±31.6 (P=0.050 vs. baseline level), and mean ICIQ-SF score was 9.5±6.6 (P=0.077 vs. baseline level). Based on 24-hour pad testing, mean daily urine loss was 31.2±64.5 g (median, 0 g; range, 0-209 g). Cure rate was 46.7%, and cure-and-improved rate was 60.0%. Assessing predictive features for success, better results were found in patients who needed up to 4 pads preoperatively (P=0.041) as well as for patients ≤71 years at the time of implantation (P=0.041).
The findings indicate that AdVance and AdVanceXP implantation can be performed effectively and safely in men suffering from SUI after TURP. However, long-term success rates seem to be lower compared to SUI after radical prostatectomy and patients should be counseled accordingly.
评估AdVance和AdVanceXP男性吊带对经尿道前列腺切除术(TURP)后持续性压力性尿失禁(SUI)患者的长期疗效。
2007年至2013年期间,共有18例连续患者接受了AdVance(n = 14)或AdVanceXP(n = 4)男性吊带植入术。通过使用尿垫、24小时尿垫测试和经过验证的问卷(国际尿失禁咨询问卷简表,ICIQ - SF)来确定尿失禁情况。通过国际生活质量(IQoL)评分评估生活质量。用患者对改善情况的总体印象评分来衡量患者满意度。治愈定义为24小时尿垫测试漏尿量为0 - 5克。统计分析包括Fisher精确检验和Wilcoxon检验(P < 0.05)。
15例患者可供随访并进行进一步分析。中位随访70个月(范围18 - 83个月)后,平均每日尿垫使用量为1.8±2.1片(与基线水平相比,P = 0.015)。平均IQoL评分为66.4±31.6(与基线水平相比,P = 0.050),平均ICIQ - SF评分为9.5±6.6(与基线水平相比,P = 0.077)。基于24小时尿垫测试,平均每日尿量损失为31.2±64.5克(中位数为0克;范围为0 - 209克)。治愈率为46.7%,治愈加改善率为60.0%。评估成功的预测特征发现,术前需要最多4片尿垫的患者(P = 0.041)以及植入时年龄≤71岁的患者(P = 0.041)效果更好。
研究结果表明,对于TURP后患有SUI的男性,AdVance和AdVanceXP植入术可以有效且安全地进行。然而,与根治性前列腺切除术后的SUI相比,长期成功率似乎较低,应相应地对患者进行咨询。