Fomin Daren A, McDaniel Brianna, Crane Jonathan
a MS-IV, Campbell University School of Osteopathic Medicine , Lillington , NC , USA.
b Dermatology Resident, PGY-3, Sampson Regional Medical Center , Clinton , NC , USA.
J Dermatolog Treat. 2017 Sep;28(6):484-487. doi: 10.1080/09546634.2016.1276259. Epub 2017 Jan 24.
The ketogenic diet has been shown to be beneficial for numerous diseases across different organ systems, but a dearth of information exists regarding these benefits for skin disease. Here, we searched the literature for known mechanisms behind inflammation in dermatologic disease and correlated that with suggested mechanisms of anti-inflammatory activity of ketones and a ketogenic state in the human body to observe how ketones and ketosis might aid in the treatment of inflammatory skin diseases based on these mechanisms. Specifically, we found that ketones modulate the NRPL3 inflammasome, augment anti-oxidation against reactive oxygen species through various direct and indirect means, and may influence mTOR activity, which are all involved in inflammatory dermatologic diseases to an extent. This evidence shows that ketones and the ketogenic diet may have a promising role in the dermatologist's disease treatment repertoire. Our goal is to provide a novel direction for research in the role of a ketogenic diet and even exogenous ketone therapy in the treatment of inflammatory dermatologic disease.
生酮饮食已被证明对不同器官系统的多种疾病有益，但关于其对皮肤病的益处却缺乏相关信息。在此，我们在文献中搜索了皮肤病炎症背后的已知机制，并将其与酮类抗炎活性及人体生酮状态的推测机制相关联，以观察酮类和酮症如何基于这些机制辅助治疗炎症性皮肤病。具体而言，我们发现酮类可调节NLRP3炎性小体，通过多种直接和间接方式增强对活性氧的抗氧化作用，且可能影响mTOR活性，这些在一定程度上均与炎症性皮肤病有关。这一证据表明，酮类和生酮饮食可能在皮肤科医生的疾病治疗方法中发挥重要作用。我们的目标是为研究生酮饮食乃至外源性酮类疗法在炎症性皮肤病治疗中的作用提供一个新方向。
