[Effects of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of Polycyclic aromatic hydrocarbon in coal tar pitch workers].

To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch. 374 cases of workers exposed to coal tar pitch work at the enterprise which use and product coal tar pitch in Shan Dong province named as exposure group.The ad-ministrative and the support staff 135 cases were selected as control group.The concentration of the metabolic product in urine by HPLC/MC.The genetic polymorphisms of GSTT1 and GSTM1 were detected by multiple PCR method. The content of metabolic product in smoke group were significantly higher than workers do not smoke (<0.05) . The content of metabolic product in exposure group were significantly higher than control group (<0.05) . The content of metabolic product in workers carry positive GSTT1 and GSTM1 were significantly high-er than workers carry negative one (<0.05) . The content of metabolic product in different types of labor were significantly different (<0.05) . The content of metabolic product were significantly higher in urine after work than before work (<0.05) . The content of metabolic product and workers carry positive GSTT1 and GSTM1 had a positive correlation (<0.05) . Carrying positive GSTT1 and GSTM1 promote polycyclic aromatic hydrocarbons in the body's metabolism.