Samad Noreen, Farooq Samia, Hafeez Kinza, Maryam Mukharma, Rafi Muhammad Aftab
Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Coll Physicians Surg Pak. 2016 Dec;26(12):950-953.
To evaluate the biochemical consequences and platelet counts of birth asphyxia in neonates.
Cohort study.
Department of Child Health, Nishter Medical College and Hospital, Multan, from September to November 2015.
The data of 50 (50%) asphyxiated neonates and 50 (50%) non-asphyxiated neonates, with age range less than 1 month, was collected from Children Ward of Nishtar Hospital, Multan, Pakistan. Data on platelet count in blood, kidney function tests (creatinine, urea), liver function tests (bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST)) and cardiac enzyme test (lactate dehydrogenase (LDH)) were analysed by paired sample t-test by SPSS software. Sociodemographic data of those neonate's mothers was also collected.
In asphyxiated neonates LDH, ALT, AST, creatinine, bilirubin, urea levels were higher than healthy infants, while the platelet count was smaller in asphyxiated neonates than healthy infants.
There was a higher rate of alteration in platelet count, levels of LDH, AST, ALT, urea creatinine and bilirubin in asphyxiated infants. These alterations may be correlated with damage of vital organ of asphyxiated neonates.
评估新生儿出生窒息的生化后果及血小板计数。
队列研究。
2015年9月至11月，木尔坦尼什塔尔医学院附属医院儿童健康科。
从巴基斯坦木尔坦尼什塔尔医院儿童病房收集50例（50%）窒息新生儿和50例（50%）非窒息新生儿的数据，年龄均小于1个月。通过SPSS软件采用配对样本t检验分析血液中血小板计数、肾功能检查（肌酐、尿素）、肝功能检查（胆红素、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST））及心肌酶检查（乳酸脱氢酶（LDH））的数据。还收集了这些新生儿母亲的社会人口统计学数据。
窒息新生儿的LDH、ALT、AST、肌酐、胆红素、尿素水平高于健康婴儿，而窒息新生儿的血小板计数低于健康婴儿。
窒息婴儿的血小板计数、LDH、AST、ALT、尿素、肌酐和胆红素水平的改变率较高。这些改变可能与窒息新生儿重要器官的损伤有关。
