He S, Bremme K, Kallner A, Blombäck M
Department of Laboratory Medicine/Blood Coagulation Research, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Gynecol Obstet Invest. 1995;39(4):234-8. doi: 10.1159/000292417.
Lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations and platelet counts were measured in 26 normal pregnant women and 51 preeclamptic women. In the normal-pregnancy group, no significant changes were found in the results of these tests. In the preeclampsia group, ALT and AST concentrations were not significantly higher than those in normal pregnancy, but the LDH concentrations increased and the platelet counts decreased significantly through the pregnancy. The increases in LDH did not correlate with changes in ALT or AST. Preeclamptic women with small-for-gestational-age (SGA) infants had significantly higher LDH concentrations than those in the appropriate-for-gestational-age (AGA) group, but ALT and AST concentrations did not increase significantly. As reasons for the LDH increase in our subjects, liver damage was excluded and more active glycolysis in addition to severe cell damage due to chronic anoxemia were inferred. It is suggested that an increase in LDH is predictive of SGA infants in preeclamptic pregnancy, especially in those with normal liver function.
对26名正常孕妇和51名先兆子痫妇女测量了乳酸脱氢酶（LDH）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）浓度及血小板计数。在正常妊娠组，这些检测结果未发现显著变化。在先兆子痫组，ALT和AST浓度并不显著高于正常妊娠组，但整个孕期LDH浓度升高，血小板计数显著下降。LDH的升高与ALT或AST的变化无关。有小于胎龄儿（SGA）的先兆子痫妇女的LDH浓度显著高于适于胎龄儿（AGA）组，但ALT和AST浓度未显著升高。作为我们研究对象中LDH升高的原因，排除了肝损伤，并推断除了慢性缺氧导致的严重细胞损伤外，还有更活跃的糖酵解。提示LDH升高可预测先兆子痫妊娠中的SGA婴儿，尤其是肝功能正常者。
