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[肿瘤细胞中抗氧化酶活性低下作为巨噬细胞抗肿瘤细胞毒性氧依赖性的一个因素]

[Low activity of antioxidant enzymes in tumor cells as a factor of oxygen dependence of antitumor cytotoxicity of macrophages].

作者信息

Borunov E V, Khavalkin I V, Smirnova L P, Shchepetkin I A, Lankin V Z, Vasil'ev N V

出版信息

Biull Eksp Biol Med. 1989 Aug;108(8):233-5.

PMID:2804332
Abstract

The author studied dependence of cytotoxicity of peritoneal macrophages of Wistar rats on the production of active oxygen form (AOF) and activity of antioxidative enzymes in target cells. Low activity of glutathione-peroxidase and glutathione-reductase in K562 cells could be the cause of macrophage cytotoxicity realization along AOF-dependent way.

摘要

作者研究了Wistar大鼠腹腔巨噬细胞的细胞毒性对活性氧形式（AOF）产生及靶细胞中抗氧化酶活性的依赖性。K562细胞中谷胱甘肽过氧化物酶和谷胱甘肽还原酶的低活性可能是巨噬细胞沿AOF依赖性途径实现细胞毒性的原因。

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