Khan Nadeem, Michael Alex, Choucair Ali, Bit-Ivan Esther
Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Department of Neurosurgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
World Neurosurg. 2017 Mar;99:811.e7-811.e10. doi: 10.1016/j.wneu.2016.12.085. Epub 2016 Dec 30.
Intracranial ganglioneuromas are very rare benign tumors of neural crest origin and generally arise from the peripheral nervous system or adrenal glands. Very few cases of intracranial ganglioneuroma arising from the trigeminal nerve have been reported in the literature, all in East Asia.
A 52-year-old male presented to his primary care physician for evaluation of right facial and periorbital pain for over 18 months. He also reported a two-week history of diplopia with right lateral gaze, which resolved spontaneously. An MRI brain with and without contrast revealed a 3.0 × 2.6 × 2.4 cm enhancing extra-axial mass involving right Meckel's cave with a posterior 1.0 × 1.4 cm lobular component protruding into the prepontine cistern. The patient underwent a right middle fossa craniotomy for a subtemporal surgical resection of the tumor. Histologic section of the tumor demonstrated mature ganglion cells with surrounding satellite cells in a schwannian rich stroma, consistent with mature type ganglioneuroma.
To the best of our knowledge, this is the sixth case of trigeminal ganglioneuroma; however, it is the first case reported in the United States.
颅内神经节细胞瘤是非常罕见的起源于神经嵴的良性肿瘤，通常起源于周围神经系统或肾上腺。文献中报道的极少几例起源于三叉神经的颅内神经节细胞瘤均来自东亚地区。
一名52岁男性因右侧面部及眶周疼痛超过18个月就诊于其初级保健医生。他还报告有右侧外展时复视2周病史，该症状自行缓解。头颅磁共振成像（MRI）平扫及增强扫描显示一个3.0×2.6×2.4 cm强化的轴外肿块，累及右侧Meckel腔，后方有一个1.0×1.4 cm的小叶成分突入脑桥前池。患者接受了右侧中颅窝开颅术，经颞下入路手术切除肿瘤。肿瘤组织学切片显示成熟的神经节细胞，周围有卫星细胞，存在于富含雪旺细胞的基质中，符合成熟型神经节细胞瘤。
据我们所知，这是第六例三叉神经神经节细胞瘤；然而，这是美国报道的首例。
