Department of Thoracic Surgery, Ganzhou People's Hospital, Nanchang University, Ganzhou, China.
Medicine (Baltimore). 2023 Jun 9;102(23):e33891. doi: 10.1097/MD.0000000000033891.
Ganglioneuroma (GN) is a rare tumor that originates from neural crest cells and can manifest in any location along the sympathetic chain. It typically exhibits a circular or oval shape and does not invade the surrounding tissue destructively and the enormous lobular appearance and erosion of adjacent skeletal tissues are extremely infrequent among GN.
A 15-year-old girl presented to our thoracic surgery clinic with a large intrathoracic mass that was incidentally discovered on a chest X-ray. Further imaging with computed tomography and magnetic resonance imaging revealed a lobular profile and an aggressive growth pattern of the tumor, which destroyed the vertebral and rib bones. A tissue sample obtained by needle biopsy was subjected to histopathological analysis, which confirmed the diagnosis of a GN.
Thoracic (posterior mediastinal) GN and Hashimoto's thyroiditis.
After thoracoscopic exploration, a thoracotomy was performed to excise the mass.
The patient recovered well after surgery, had no major complications, and was discharged without any issues. Further follow-up is necessary to clarify the medium to long-term outcome.
Based on existing reports, thoracic GN rarely erodes adjacent bone tissue. By examining previously reported cases, we speculate that the lobular morphology of the tumor may be linked to the more aggressive biological behavior of GN. We also discovered that female patients may be more susceptible to bone erosion. However, further research and additional cases are required to confirm these potential associations.
神经节细胞瘤（GN）是一种起源于神经嵴细胞的罕见肿瘤，可发生在交感神经链的任何部位。它通常表现为圆形或椭圆形，不会破坏性地侵犯周围组织，巨大的分叶状外观和相邻骨骼组织的侵蚀在 GN 中极为罕见。
一名 15 岁女孩因胸部 X 光片偶然发现巨大的胸腔内肿块而到我院胸外科就诊。进一步的计算机断层扫描和磁共振成像显示肿瘤具有分叶状特征和侵袭性生长模式，破坏了椎骨和肋骨。通过针吸活检获得的组织样本进行了组织病理学分析，证实了 GN 的诊断。
胸（后纵隔）GN 和桥本甲状腺炎。
在胸腔镜探查后，进行了开胸手术切除肿块。
患者术后恢复良好，无重大并发症，无问题出院。需要进一步随访以明确中远期结果。
根据现有报告，胸 GN 很少侵蚀相邻骨组织。通过检查以前报道的病例，我们推测肿瘤的分叶形态可能与 GN 更具侵袭性的生物学行为有关。我们还发现女性患者可能更容易发生骨侵蚀。然而，需要进一步的研究和更多的病例来证实这些潜在的关联。
