Kim Seung-Hyun, Behnes Michael, Natale Michele, Hoffmann Julia, Reckord Nadine, Hoffmann Ursula, Budjan Johannes, Henzler Thomas, Papavassiliu Theano, Borggrefe Martin, Bertsch Thomas, Akin Ibrahim
First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, Heidelberg University, Mannheim, Germany.
Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, Heidelberg University, Mannheim, Germany.
Dis Markers. 2016;2016:7402784. doi: 10.1155/2016/7402784. Epub 2016 Dec 1.
. This study investigates whether serum levels of galectin-3 may reflect impaired mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). . Patients undergoing cMRI during routine clinical care were included prospectively within an all-comers design. Blood samples for biomarker measurements were collected within 24 hours following cMRI. Statistical analyses were performed in all patients and in three subgroups according to MAPSE (MAPSE I: ≥11 mm, MAPSE II: ≥8 mm-<11 mm, and MAPSE III: <8 mm). Patients with right ventricular dysfunction (<50%) were excluded. . 84 patients were included in the study. Median LVEF was 59% (IQR 51-64%). Galectin-3 correlated significantly with NT-proBNP ( = 0.42, = 0.0001). Galectin-3 increased significantly according to the different stages of impaired MAPSE ( = 0.006) and was able to discriminate both patients with impaired MAPSE <11 mm (area under the curve (AUC) = 0.645, = 0.024) and <8 mm (AUC = 0.733, = 0.003). Combining galectin-3 with NT-proBNP improved discrimination of MAPSE <8 mm (AUC 0.803, = 0.0001). In multivariable logistic regression models galectin-3 was still associated with impaired MAPSE (MAPSE < 11 mm: odds ratio (OR) = 3.53, = 0.018; MAPSE < 8 mm: OR = 3.18, = 0.06). . Galectin-3 reflects MAPSE being assessed by cardiac MRI.
本研究调查了在接受心脏磁共振成像（cMRI）的患者中，半乳糖凝集素-3的血清水平是否可反映二尖瓣环平面收缩期位移（MAPSE）受损情况。在常规临床护理期间接受cMRI检查的患者以前瞻性、所有患者纳入的设计被纳入研究。在cMRI检查后24小时内采集用于生物标志物测量的血样。对所有患者以及根据MAPSE划分的三个亚组（MAPSE I：≥11毫米，MAPSE II：≥8毫米-<11毫米，MAPSE III：<8毫米）进行统计分析。排除右心室功能不全（<50%）的患者。84名患者被纳入本研究。左心室射血分数（LVEF）中位数为59%（四分位间距51-64%）。半乳糖凝集素-3与N末端B型利钠肽原（NT-proBNP）显著相关（r = 0.42，P = 0.0001）。半乳糖凝集素-3根据MAPSE受损的不同阶段显著升高（P = 0.006），并且能够区分MAPSE<11毫米的受损患者（曲线下面积（AUC）= 0.645，P = 0.024）和<8毫米的患者（AUC = 0.733，P = 0.003）。将半乳糖凝集素-3与NT-proBNP联合使用可改善对MAPSE<8毫米的鉴别诊断（AUC 0.803，P = 0.0001）。在多变量逻辑回归模型中，半乳糖凝集素-3仍与MAPSE受损相关（MAPSE<11毫米：比值比（OR）= 3.53，P = 0.018；MAPSE<8毫米：OR = 3.18，P = 0.06）。半乳糖凝集素-3反映了通过心脏磁共振成像评估的MAPSE。
