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放射治疗诱发的正常组织并发症建模：超越现象学模型的概述

Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models.

作者信息

D'Andrea Marco, Benassi Marcello, Strigari Lidia

机构信息

Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.

出版信息

Comput Math Methods Med. 2016;2016:2796186. doi: 10.1155/2016/2796186. Epub 2016 Dec 1.

DOI:10.1155/2016/2796186
PMID:28044088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5156873/
Abstract

An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points.

摘要

本文概述了放射治疗（RT）诱发的正常组织并发症概率（NTCP）模型。回顾了基于经验和机制方法的NTCP模型，这些模型描述了随着时间推移针对传统放疗提出的特定辐射诱发的晚期效应，特别强调了它们的基本假设、相关的数学转换以及优缺点。

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本文引用的文献

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Comparison of dose response models for predicting normal tissue complications from cancer radiotherapy: application in rat spinal cord.比较预测癌症放射治疗中正常组织并发症的剂量反应模型：在大鼠脊髓中的应用。
Cancers (Basel). 2011 May 18;3(2):2421-43. doi: 10.3390/cancers3022421.
2
The use and QA of biologically related models for treatment planning: short report of the TG-166 of the therapy physics committee of the AAPM.治疗计划中生物学相关模型的使用和质量保证：AAPM 治疗物理学委员会 TG-166 的简短报告。
Med Phys. 2012 Mar;39(3):1386-409. doi: 10.1118/1.3685447.
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Mechanistic simulation of normal-tissue damage in radiotherapy--implications for dose-volume analyses.放射治疗中正常组织损伤的机制模拟——对剂量-体积分析的影响。
Phys Med Biol. 2010 Apr 21;55(8):2121-36. doi: 10.1088/0031-9155/55/8/001. Epub 2010 Mar 19.
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Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues.临床正常组织效应的定量分析（QUANTEC）：科学问题简介。
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S3-9. doi: 10.1016/j.ijrobp.2009.09.040.
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A role for biological optimization within the current treatment planning paradigm.生物优化在当前治疗计划范式中的作用。
Med Phys. 2009 Oct;36(10):4672-82. doi: 10.1118/1.3220211.
6
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy.通用生存曲线和单次分割等效剂量：理解消融性放射治疗效能的有用工具。
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):847-52. doi: 10.1016/j.ijrobp.2007.10.059.
7
A new formula for normal tissue complication probability (NTCP) as a function of equivalent uniform dose (EUD).一种作为等效均匀剂量（EUD）函数的正常组织并发症概率（NTCP）新公式。
Phys Med Biol. 2008 Jan 7;53(1):23-36. doi: 10.1088/0031-9155/53/1/002. Epub 2007 Dec 13.
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Physical models and simpler dosimetric descriptors of radiation late toxicity.辐射晚期毒性的物理模型和更简单的剂量学描述符。
Semin Radiat Oncol. 2007 Apr;17(2):108-20. doi: 10.1016/j.semradonc.2006.11.007.
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Optimization of intensity-modulated radiation therapy with biological objectives.
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Method to account for dose fractionation in analysis of IMRT plans: modified equivalent uniform dose.
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