Li X H, Guan L Y, Lin H Y, Wang S H, Cao Y Q, Jiang X Y, Wang Y B
Health Management Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
J Diabetes Res. 2016;2016:2358321. doi: 10.1155/2016/2358321. Epub 2016 Dec 1.
. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). . A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted to our hospital between January 2015 and January 2016. In total, 152 patients with DFU were enrolled in the study group, and 52 age and gender matched people with diabetes but no DFU were included as the control group. DFU severity was assessed using Wagner criteria. . Patients with DFU were divided into 2 subgroups based on the Wagner criteria. Mean fibrinogen values were significantly higher in patients with DFU grade ≧ 3 compared to those with DFU grades 1-2 (5.23 ± 1.37 g/L versus 3.61 ± 1.04 g/L). Using ROC statistic, a cut-off value of 5.13 g/L indicated the possible amputation with a sensitivity of 81.8% and a specificity of 78.9% (positive predictive value [PPV] 78.6%, negative predictive value [89.0%]). Fibrinogen values were found to be correlated with CRP levels, neutrophil, and WBC count. . Fibrinogen levels might be a valuable tool for assessing the disease severity and monitoring the disease progression in patients with DFU.
研究纤维蛋白原水平是否为评估糖尿病足溃疡（DFU）患者疾病严重程度及监测疾病进展的有价值生物标志物。
一项回顾性研究旨在探讨2015年1月至2016年1月期间我院收治的DFU患者中纤维蛋白原在评估疾病严重程度方面的作用。研究组共纳入152例DFU患者，52例年龄和性别匹配的糖尿病但无DFU患者作为对照组。采用Wagner标准评估DFU严重程度。
根据Wagner标准将DFU患者分为2个亚组。DFU 3级及以上患者的纤维蛋白原均值显著高于1 - 2级患者（5.23±1.37g/L对3.61±1.04g/L）。通过ROC统计分析，5.13g/L的临界值提示可能需要截肢，敏感性为81.8%，特异性为78.9%（阳性预测值[PPV]78.6%，阴性预测值89.0%）。发现纤维蛋白原水平与CRP水平、中性粒细胞及白细胞计数相关。
纤维蛋白原水平可能是评估DFU患者疾病严重程度及监测疾病进展的有价值工具。
