通过光氧化还原催化实现苯并咪唑的选择性C-H三氟甲基化反应。
Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis.
作者信息
Gao Guo-Lin, Yang Chao, Xia Wujiong
机构信息
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150080, China.
出版信息
Chem Commun (Camb). 2017 Jan 17;53(6):1041-1044. doi: 10.1039/c6cc08975e.
The protocol presented here is a new strategy for visible light induced C-H trifluoromethylation at C of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy). Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.
本文介绍的方案是一种在 fac-Ir(ppy) 存在下使用托格尼试剂对苯并咪唑的 C 进行可见光诱导 C-H 三氟甲基化的新策略。其优点是操作简单、反应条件温和、催化剂负载量低且底物范围广，吸电子、供电子基团以及不同的保护基团均可耐受。
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