在吲哚的C2位上使用CF₃SO₂Na进行无金属氧化三氟甲基化反应。
Metal-free oxidative trifluoromethylation of indoles with CFSONa on the C2 position.
作者信息
Xie Jiao-Jiao, Wang Zhi-Qing, Jiang Guo-Fang
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 P. R. China
出版信息
RSC Adv. 2019 Oct 30;9(60):35098-35101. doi: 10.1039/c9ra07785e. eCollection 2019 Oct 28.
Abstract
An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CFSONa under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.
摘要
描述了一种在无金属条件下，以易于操作、廉价且低毒的CFSONa从吲哚合成2-三氟甲基吲哚的有效方法，该方法可选择性地将三氟甲基引入吲哚的C2位。所需产物的产率可达0.7 g。该转化过程可能涉及自由基中间体。
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