微小RNA-190b通过对胃癌细胞中Bcl-2的负调控赋予放射敏感性。
MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells.
作者信息
Wang Changzheng, Qiao Chuanhu
机构信息
Department of Gastroenterology, The First People's Hospital of XiangYang, Hubei University of Medicine, No. 15, Jiefang Road, Fancheng District, Xiangyang, 441000, Hubei, People's Republic of China.
出版信息
Biotechnol Lett. 2017 Apr;39(4):485-490. doi: 10.1007/s10529-016-2273-2. Epub 2017 Jan 2.
OBJECTIVES
To determine the role of miR-190b in radio-sensitivity of gastric cancer (GC).
RESULTS
In radio-resistant GC cells, down-regulation of miR-190b and up-regulation of Bcl-2 were observed. The protein expression of Bcl-2 was negatively regulated by miR-190b. Overexpression of miR-190b significantly decreased cell viability and enhanced radio-sensitivity of GC cells. Of note, these effects of miR-190b on GC cells radio-sensitivity were abolished by Bcl-2.
CONCLUSION
miR-190b confers radio-sensitivity of GC cells, possibly via negative regulation of Bcl-2.
目的
确定miR-190b在胃癌（GC）放射敏感性中的作用。
结果
在放射抗性GC细胞中，观察到miR-190b下调和Bcl-2上调。miR-190b对Bcl-2的蛋白表达具有负调控作用。miR-190b的过表达显著降低了GC细胞的活力并增强了其放射敏感性。值得注意的是，miR-190b对GC细胞放射敏感性的这些作用被Bcl-2消除。
结论
miR-190b可能通过对Bcl-2的负调控赋予GC细胞放射敏感性。
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