Kong Xianglei, Xu Dayu, Li Feng, Ma Xiaojing, Su Hong, Xu Dongmei
Department of Nephrology, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, 250014, Jinan, People's Republic of China.
Medical College, Shandong University, No.44, Wenhua West Road, Jinan, China.
Int Urol Nephrol. 2017 May;49(5):845-850. doi: 10.1007/s11255-016-1498-2. Epub 2017 Jan 2.
Some studies have suggested that Helicobacter pylori (H. Pylori) infection was associated with insulin resistance and metabolic syndrome, which may increase the risk of chronic kidney disease (CKD). But there is no conclusive evidence regarding the association between H. Pylori infection and CKD. To help clarify this, we conducted the cross-sectional study to investigate the association of H. pylori infection with CKD among Chinese adults.
A total of 22,044 adults aged 48.6 ± 14.3 years were enrolled. H. pylori-specific immunoglobulin G antibody titers were measured by ELISA. CKD was defined as estimated glomerular filtration rate (eGFR) less than <60 ml/min/1.73 m or presence of proteinuria (urine protein ≥ 1+) assessed using a repeated dipstick method.
Among all participants in this study, the prevalence of H. Pylori infection was 20.6%. As a categorical outcome, the prevalence of decreased eGFR in the H. Pylori infection group was higher than in the non-H. Pylori infection group (1.6 vs. 1.2%, P = 0.04), but the prevalence of proteinuria and the overall CKD were not significantly different between these two groups (1.7 vs. 1.6%, P = 0.65 and 3.0 vs. 2.7%, P = 0.2). After adjusted for age, sex, hypertension, diabetes, body mass index, uric acid, smoking, drinking, total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, the odds of decreased eGFR and proteinuria were not significantly different between the H. Pylori positive and negative subjects.
This study did not find an association between H. Pylori infection and CKD.
一些研究表明，幽门螺杆菌（H. Pylori）感染与胰岛素抵抗和代谢综合征有关，这可能会增加慢性肾脏病（CKD）的风险。但关于幽门螺杆菌感染与慢性肾脏病之间的关联尚无确凿证据。为了阐明这一点，我们进行了一项横断面研究，以调查中国成年人中幽门螺杆菌感染与慢性肾脏病的关联。
共纳入22,044名年龄为48.6±14.3岁的成年人。通过酶联免疫吸附测定法（ELISA）测量幽门螺杆菌特异性免疫球蛋白G抗体滴度。慢性肾脏病的定义为估算肾小球滤过率（eGFR）低于<60 ml/min/1.73 m²或存在蛋白尿（尿蛋白≥1+），采用重复试纸法进行评估。
在本研究的所有参与者中，幽门螺杆菌感染的患病率为20.6%。作为分类结果，幽门螺杆菌感染组中eGFR降低的患病率高于非幽门螺杆菌感染组（1.6%对1.2%，P = 0.04），但两组之间蛋白尿患病率和总体慢性肾脏病患病率无显著差异（1.7%对1.6%，P = 0.65；3.0%对2.7%，P = 0.2）。在调整年龄、性别、高血压、糖尿病、体重指数、尿酸、吸烟、饮酒、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇后，幽门螺杆菌阳性和阴性受试者之间eGFR降低和蛋白尿的几率无显著差异。
本研究未发现幽门螺杆菌感染与慢性肾脏病之间存在关联。
