Parisotto Stefano, Lace Beatrice, Artuso Emma, Lombardi Chiara, Deagostino Annamaria, Scudu Roberto, Garino Claudio, Medana Claudio, Prandi Cristina
Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, 10125 Torino, Italy.
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Italy.
Org Biomol Chem. 2017 Jan 25;15(4):884-893. doi: 10.1039/c6ob02602h.
As part of our ongoing work on the synthesis of a new class of plant hormones named Strigolactones (SLs) and their analogues, we became interested in tracing bioactive molecules with red emitting BODIPY fluorophores in order to unravel signaling and distribution of SLs in plants. In this paper we report on an unprecedented Heck functionalization of azadipyrromethenes (aza-DIPY) which allows for the introduction of suitable functional groups to convert aza-BODIPY in bioconjugate complexes useful for untangling biological processes.
作为我们正在进行的关于一类名为独脚金内酯（SLs）的新型植物激素及其类似物合成工作的一部分，我们开始关注用发射红色荧光的BODIPY荧光团追踪生物活性分子，以便揭示SLs在植物中的信号传导和分布情况。在本文中，我们报道了氮杂二吡咯亚甲基（aza-DIPY）前所未有的Heck官能化反应，该反应能够引入合适的官能团，将氮杂BODIPY转化为可用于阐明生物过程的生物共轭复合物。
