Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong, P. R. China.
Org Lett. 2017 Jan 20;19(2):308-311. doi: 10.1021/acs.orglett.6b03295. Epub 2017 Jan 3.
A highly efficient palladium-catalyzed intramolecular aminoalkylation of unactivated alkenes in the absence of an external ligand and oxidant is described. New C-N and C(sp)-C(sp) bonds are formed simultaneously. This general transformation allows for construction of diverse N-heterocycles. Mechanistic studies show that the process may involve a four-membered Pd(alkyl)amido intermediate.
本文报道了一种在无外加配体和氧化剂的情况下，高效钯催化的未活化烯烃的分子内氨基烷基化反应。新的 C-N 和 C(sp)-C(sp)键同时形成。这种通用的转化方法可用于构建多种 N-杂环化合物。机理研究表明，该过程可能涉及到一个四元 Pd(烷基)酰胺中间体。
