利用振动圆二色性分析碳水化合物和核苷中呋喃糖环的构象和构象。

Analysis of Configuration and Conformation of Furanose Ring in Carbohydrate and Nucleoside by Vibrational Circular Dichroism.

机构信息

Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, and ‡Graduate School of Life Science, Hokkaido University , Kita 21 Nishi 11, Sapporo 001-0021, Japan.

出版信息

Org Lett. 2017 Jan 20;19(2):404-407. doi: 10.1021/acs.orglett.6b03626. Epub 2017 Jan 3.

DOI:10.1021/acs.orglett.6b03626

PMID:28045273

Abstract

A reliable and convenient method for determining the configuration and conformation of the furanose ring in carbohydrates and nucleosides by vibrational circular dichroism (VCD) spectroscopy is described. Diastereomeric pairs of several furanose monosaccharides and nucleosides were prepared, and their VCD spectra were analyzed. The results revealed that VCD spectroscopy elucidates the equibrated state of the furanose ring puckers, which is often difficult to study by other techniques.

摘要

本文描述了一种通过振动圆二色性（VCD）光谱法测定碳水化合物和核苷中环呋喃糖的构型和构象的可靠、便捷方法。本文制备了几对非对映异构体的呋喃单糖和核苷，并对它们的 VCD 光谱进行了分析。结果表明，VCD 光谱法阐明了呋喃糖环褶皱的平衡态，这通常很难用其他技术进行研究。