药物化学中的S-糖苷：氰基乙烯硫代糖苷及其吡唑衍生物的新合成方法
S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives.
作者信息
Elgemeie Galal, Fathy Nahed, Zaghary Wafaa, Farag Ayman
机构信息
a Chemistry Department , Faculty of Science, Helwan University , Helwan , Cairo , Egypt.
b Photochemistry Department , National Research Centre , Dokki , Cairo , Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2017 Mar 4;36(3):198-212. doi: 10.1080/15257770.2016.1257807. Epub 2017 Jan 3.
Abstract
A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-configuration of these cyanoethylene thioglycosides.
摘要
2-氰基乙烯-1-硫醇钠盐水合物与2,3,4,6-四-O-乙酰基-α-D-葡萄糖和半乳糖吡喃糖基溴的一锅反应得到了一类新型的氰基乙烯硫代糖苷。转化为相应的5-氨基吡唑证实了这些氰基乙烯硫代糖苷的E-构型。
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