Orgun Doruk, Horiguchi Masatoshi, Hayashi Ayato, Shimoji Kazuaki, Arai Hajime, Mizuno Hiroshi
*Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine †Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
J Craniofac Surg. 2017 Mar;28(2):e154-e158. doi: 10.1097/SCS.0000000000003347.
The object of this report is to share our experience of conservative management of giant aplasia cutis congenita (ACC) of the scalp with the topical application of basic fibroblast growth factor (bFGF). Complete epithelialization of the 9 × 8 cm sized defect was achieved in 33 weeks. Careful conservative management could eliminate the requirement of surgery for giant ACC defects of the scalp with bone defects and should be tried if surgery is thought to be risky or has consecutive morbidity. Topical bFGF application seems to accelerate healing, also providing a better epithelium for later reconstructive treatments and its usage could be standardized in the future.
本报告的目的是分享我们使用碱性成纤维细胞生长因子（bFGF）局部应用保守治疗巨大先天性皮肤发育不全（ACC）头皮缺损的经验。9×8厘米大小的缺损在33周内实现了完全上皮化。仔细的保守治疗可以消除对伴有骨缺损的巨大ACC头皮缺损进行手术的必要性，如果认为手术有风险或会带来一系列并发症，就应尝试保守治疗。局部应用bFGF似乎能加速愈合，还能为后续的重建治疗提供更好的上皮组织，其使用在未来可以标准化。
