Andriolo Luca, Merli Giulia, Filardo Giuseppe, Marcacci Maurilio, Kon Elizaveta
†Nano-Biotechnology Laboratory *I Orthopaedic and Traumatologic Clinic Rizzoli Orthopaedic Institute, Bologna, Italy.
Sports Med Arthrosc Rev. 2017 Mar;25(1):10-18. doi: 10.1097/JSA.0000000000000137.
Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation. Failures are very heterogenously defined in the current literature. A widely accepted definition is needed, and a comprehensive definition taking into consideration the patient's perception of the outcome, not just the surgeon's or researcher's point of view, would be advisable. Finally, there is no agreement on the most appropriate treatment of failures, and further studies are needed to give better indications to properly manage patients failed after cartilage procedures.
Level IV.
自体软骨细胞移植和基质辅助自体软骨细胞移植治疗膝关节的长期效果令人满意，但对失败病例的评估关注不足。因此，我们对文献进行了系统回顾，在所纳入的4294例患者的58篇文章中，失败率为14.9%，大多数失败发生在术后前5年，自体软骨细胞移植和基质辅助自体软骨细胞移植之间无差异。目前文献中对失败的定义非常不一致。需要一个被广泛接受的定义，考虑患者对结果的认知，而不仅仅是外科医生或研究者观点的综合定义是可取的。最后，对于失败病例的最佳治疗方法尚无共识，需要进一步研究以更好地指导软骨手术失败患者的合理管理。
四级。
