Hsu Shih-Ming, Hung Chao-Hsiung, Liao Yi-Jen, Fu Hsiao-Mei, Tsai Jo-Ting, Huang Yung-Hui, Huang David Y C
Medical Physics and Radiation Measurements Laboratory, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
PLoS One. 2017 Jan 3;12(1):e0169252. doi: 10.1371/journal.pone.0169252. eCollection 2017.
CyberKnife is one of multiple modalities for stereotactic radiosurgery (SRS). Due to the nature of CyberKnife and the characteristics of SRS, dose evaluation of the CyberKnife procedure is critical. A radiophotoluminescent glass dosimeter was used to verify the dose accuracy for the CyberKnife procedure and validate a viable dose verification system for CyberKnife treatment. A radiophotoluminescent glass dosimeter, thermoluminescent dosimeter, and Kodak EDR2 film were used to measure the lateral dose profile and percent depth dose of CyberKnife. A Monte Carlo simulation for dose verification was performed using BEAMnrc to verify the measured results. This study also used a radiophotoluminescent glass dosimeter coupled with an anthropomorphic phantom to evaluate the accuracy of the dose given by CyberKnife. Measurements from the radiophotoluminescent glass dosimeter were compared with the results of a thermoluminescent dosimeter and EDR2 film, and the differences found were less than 5%. The radiophotoluminescent glass dosimeter has some advantages in terms of dose measurements over CyberKnife, such as repeatability, stability, and small effective size. These advantages make radiophotoluminescent glass dosimeters a potential candidate dosimeter for the CyberKnife procedure. This study concludes that radiophotoluminescent glass dosimeters are a promising and reliable dosimeter for CyberKnife dose verification with clinically acceptable accuracy within 5%.
射波刀是立体定向放射外科手术（SRS）的多种方式之一。由于射波刀的特性和SRS的特点，射波刀治疗过程中的剂量评估至关重要。使用放射性光致发光玻璃剂量计来验证射波刀治疗过程中的剂量准确性，并验证一种可行的射波刀治疗剂量验证系统。使用放射性光致发光玻璃剂量计、热释光剂量计和柯达EDR2胶片来测量射波刀的侧向剂量分布和百分深度剂量。使用BEAMnrc进行剂量验证的蒙特卡罗模拟以验证测量结果。本研究还使用与人体模型耦合的放射性光致发光玻璃剂量计来评估射波刀给予剂量的准确性。将放射性光致发光玻璃剂量计的测量结果与热释光剂量计和EDR2胶片的结果进行比较，发现差异小于5%。放射性光致发光玻璃剂量计在射波刀剂量测量方面具有一些优势，例如可重复性、稳定性和有效尺寸小。这些优势使放射性光致发光玻璃剂量计成为射波刀治疗过程中潜在的候选剂量计。本研究得出结论，放射性光致发光玻璃剂量计是一种有前景且可靠的剂量计，用于射波刀剂量验证，临床可接受的准确度在5%以内。
