Rascol O, Clanet M, Montastruc J L, Simonetta M, Soulier-Esteve M J, Doyon B, Rascol A
Department of Medical and Clinical Pharmacology (INSERM U317), Centre Hospitalier Universitaire Purpan, Toulouse, France.
Brain. 1989 Oct;112 ( Pt 5):1193-214. doi: 10.1093/brain/112.5.1193.
Quantitated automated electro-oculographic data from 45 parkinsonian patients were compared with those from 30 normal control subjects. Patients were selected with idiopathic Parkinson's disease without other associated neurological disease or dementia; 20 had never received antiparkinsonian drugs and in 25 such treatment had been stopped for at least 2 days. Saccade latency, amplitude and peak velocity, smooth pursuit peak velocity, optokinetic nystagmus (OKN) maximal and mean velocities and vestibulo-ocular reflex (VOR) suppression by vision or imagination were significantly altered in patients, whereas VOR gain in darkness was normal. Alterations of saccade latency and smooth pursuit peak velocity were more severe in the more advanced stages of the disease and saccade latency directed towards the symptomatic side was slightly delayed in hemiparkinsonian patients. Saccade amplitude improved 90 min after a single oral dose of L-DOPA. These results suggest a possible dopaminergic control of some ocular movements.
对45例帕金森病患者的定量自动眼电图数据与30例正常对照者的数据进行了比较。入选的患者为特发性帕金森病，无其他相关神经疾病或痴呆；20例从未接受过抗帕金森病药物治疗，25例已停药至少2天。患者的扫视潜伏期、幅度和峰值速度、平稳跟踪峰值速度、视动性眼震（OKN）最大和平均速度以及视觉或想象对视眼反射（VOR）的抑制均有显著改变，而黑暗中VOR增益正常。疾病晚期扫视潜伏期和平稳跟踪峰值速度的改变更为严重，偏侧帕金森病患者向症状侧的扫视潜伏期略有延迟。单次口服左旋多巴90分钟后扫视幅度改善。这些结果提示多巴胺能可能对某些眼球运动有控制作用。
