Yee R D, Baloh R W, Marder S R, Levy D L, Sakala S M, Honrubia V
Jules Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine, USA.
Invest Ophthalmol Vis Sci. 1987 Feb;28(2):366-74.
Smooth pursuit and other eye movements were quantitatively studied in patients with chronic schizophrenia to characterize the pattern and severity of eye movement abnormalities in this disorder. Twenty-one patients with schizophrenia, 13 patients with other psychiatric disorders (manic-depressive psychosis, schizoaffective disorder, depression and obsessive-compulsive disorder), and 19 normal subjects were studied. Horizontal eye movements were recorded with DC electro-oculography and analyzed by an online computer system. Eye velocity and closed-loop gain of pursuit, optokinetic nystagmus (OKN), vestibulo-ocular response (VOR) and visual-vestibular interactions were calculated. The latency, accuracy and peak velocity-amplitude relationships of voluntary saccades were measured. The group mean gains of pursuit and OKN of the schizophrenic patients were significantly lower than those of the normal subjects. Suppression of the VOR by fixation was impaired, and the latency of saccades was prolonged. However, the differences in group mean values were small in magnitude, and the frequencies of outliers among the schizophrenic patients were low. The patients with other psychiatric disorders had a similar pattern and severity of eye movement abnormalities. The frequency and severity of eye movement abnormalities in schizophrenic patients are lower than those indicated by previous studies that used different techniques of analysis.
对慢性精神分裂症患者的平稳跟踪及其他眼动进行了定量研究，以明确该疾病中眼动异常的模式和严重程度。研究了21例精神分裂症患者、13例患有其他精神疾病（躁狂抑郁症、分裂情感性障碍、抑郁症和强迫症）的患者以及19名正常受试者。采用直流眼电图记录水平眼动，并通过在线计算机系统进行分析。计算了眼速度以及跟踪、视动性眼震（OKN）、前庭眼反射（VOR）和视前庭相互作用的闭环增益。测量了随意性扫视的潜伏期、准确性以及峰值速度-幅度关系。精神分裂症患者组的跟踪和OKN平均增益显著低于正常受试者。注视对VOR的抑制受损，扫视潜伏期延长。然而，组均值差异幅度较小，精神分裂症患者中异常值的频率较低。患有其他精神疾病的患者具有相似的眼动异常模式和严重程度。精神分裂症患者眼动异常的频率和严重程度低于以往使用不同分析技术的研究结果。
