Ikegami S, Nihonmatsu I, Hatanaka H, Takei N, Kawamura H
Department of Neuroscience, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Brain Res. 1989 Sep 4;496(1-2):321-6. doi: 10.1016/0006-8993(89)91081-0.
Embryonic septal neurons were transplanted into damaged hippocampus in adult rats which had received lateral ventricular administration of AF64A, a cholinergic neurotoxin. About 3 months after transplantation, the rats with bilateral septal grafts showed significant improvement in the radial maze and T-maze tasks. Many ingrowths of acetylcholinesterase (AChE)-positive fibers originating from the grafts were observed in the hippocampus of the rats which showed good performance in these learning tasks. These results indicate that transplantation of septal cholinergic neurons into the AF64A-treated hippocampus may induce at least partial recovery in learning tasks believed to involve the hippocampus.
将胚胎期的隔区神经元移植到成年大鼠受损的海马体中，这些成年大鼠此前已通过侧脑室注射胆碱能神经毒素AF64A。移植约3个月后，双侧隔区移植的大鼠在放射状迷宫和T型迷宫任务中表现出显著改善。在这些学习任务中表现良好的大鼠海马体中，观察到许多源自移植区的乙酰胆碱酯酶（AChE）阳性纤维向内生长。这些结果表明，将隔区胆碱能神经元移植到经AF64A处理的海马体中，可能会使被认为与海马体有关的学习任务至少部分恢复。
