Kaltwasser M T, Andres U
Department of Animal Physiology, University of Tübingen, F.R.G.
Brain Res. 1989 Sep 4;496(1-2):380-4. doi: 10.1016/0006-8993(89)91093-7.
Oxytocin (OXY) and cholecystokinin (CCK) coexisting in neurons of the hypothalamic paraventricular nucleus (PVN) induce grooming behavior when microinjected into the ventral tegmentum. The present study sought to investigate two other putative terminal fields of this peptide-peptide coexistence, the lateral hypothalamus (LH) and the medial preoptic area (MPOA), and to determine the functional interaction between OXY and CCK. Microinjection of OXY and CCK alone or in combination into the LH but not into the MPOA induced grooming. Both peptides seem to be equally critical for the induction of grooming; they may interact on a common substrate by suppressing each other's effect.
当微量注射到腹侧被盖区时，下丘脑室旁核（PVN）神经元中共存的催产素（OXY）和胆囊收缩素（CCK）会诱发梳理行为。本研究旨在探究这种肽 - 肽共存的另外两个假定终末场，即外侧下丘脑（LH）和内侧视前区（MPOA），并确定OXY和CCK之间的功能相互作用。单独或联合将OXY和CCK微量注射到LH而非MPOA中会诱发梳理行为。两种肽对于诱发梳理行为似乎同样关键；它们可能通过抑制彼此的作用在共同的底物上相互作用。
