Kaltwasser M T, Crawley J N
Unit on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1987 Nov 17;426(1):1-7. doi: 10.1016/0006-8993(87)90418-5.
Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive.
催产素（OXY）和胆囊收缩素（CCK）共存于大鼠下丘脑视上核和室旁核的神经元中（《细胞与组织研究》，221卷（1981年）227 - 231页）。对OXY - CCK共存的一个可能终末区域，即中脑腹侧被盖区的尾侧区域进行行为分析，以研究这种共存的功能意义。当将OXY和CCK微量注射到清醒大鼠的腹侧被盖区（VTA）时，发现二者均可诱发梳理行为。低剂量和高剂量的OXY与CCK组合所产生的梳理得分与每种肽单独诱发的梳理得分无显著差异。在这两种假定共存且无“经典”神经递质的肽的情况下，每种肽似乎都具有行为功能，且两种肽之间的相互作用可能是竞争性的。
