Shizgal P, Schindler D, Rompré P P
Department of Psychology, Concordia University, Montreal, Qué, Canada.
Brain Res. 1989 Oct 16;499(2):234-48. doi: 10.1016/0006-8993(89)90771-3.
Psychophysically derived estimates of recovery from refractoriness were obtained at self-stimulation sites in the lateral hypothalamus and ventral tegmental area. The refractory periods of single units driven by the same stimulation electrodes and stimulation fields were then measured electrophysiologically. Antidromically driven units with refractory periods longer than those of the neurons responsible for the rewarding effect were concentrated in the septal complex. Units with refractory periods that overlapped the estimates for the reward-related neurons were found in this region as well but were also encountered in neighboring structures lateral, ventral, and/or caudal to the septal nuclei. It is argued that this latter class of units should be considered as possible constituents of the directly stimulated substrate for the rewarding effect because they are driven by rewarding stimulation, have refractory periods similar to those of the reward-related neurons and arise in or near regions in which lesions have been effective in decreasing the rewarding effect of stimulating the medial forebrain bundle.
通过心理物理学方法得出了下丘脑外侧和腹侧被盖区自我刺激部位的不应期恢复估计值。然后用电生理学方法测量了由相同刺激电极和刺激场驱动的单个神经元的不应期。逆向驱动的神经元，其不应期长于负责奖赏效应的神经元，集中在隔复合体中。在该区域也发现了不应期与奖赏相关神经元的估计值重叠的神经元，但在隔核外侧、腹侧和/或尾侧的相邻结构中也有发现。有人认为，后一类神经元应被视为奖赏效应直接刺激底物的可能组成部分，因为它们由奖赏刺激驱动，具有与奖赏相关神经元相似的不应期，并且出现在损伤已有效降低刺激内侧前脑束奖赏效应的区域内或附近。
