Hartung M, Leah J, Zimmerman M
II Physiologisches Institut, Universität Heidelberg, F.R.G.
Brain Res. 1989 Oct 16;499(2):363-6. doi: 10.1016/0006-8993(89)90785-3.
Spontaneous electrophysiological activity and excitation by capsaicin of regenerating sensory fibers has been studied using 1 to 20-week-old neuromas induced in rats by ligating and transecting the saphenous nerve. Overall, spontaneous activity occurred in 12% of fibers, and capsaicin at concentrations up to 1.0 microM excited 3.8% of all the A delta-plus C-fibers examined. There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas. The responses to capsaicin were similar to those seen with normal saphenous nerve endings, including bursting discharges and desensitization with repeated applications. The results are considered in the context of the requirements for reexpression of normal sensory capacities on regenerating sensory nerve endings.
利用通过结扎和横断大鼠隐神经所诱导形成的1至20周龄神经瘤，对再生感觉纤维的自发电生理活动和辣椒素激发作用进行了研究。总体而言，12%的纤维出现自发活动，浓度高达1.0微摩尔的辣椒素激发了所检测的所有Aδ加C纤维的3.8%。随着神经瘤年龄的增加，自发活动的发生率略有增加，但辣椒素激发作用未见增加。对辣椒素的反应与正常隐神经末梢的反应相似，包括爆发性放电和重复应用后的脱敏现象。根据再生感觉神经末梢重新表达正常感觉能力的要求对这些结果进行了考量。
