Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia.

作者信息

Kanemitsu H, Tamura A, Kirino T, Oka H, Sano K, Iwamoto T, Yoshiura M, Iriyama K

机构信息

Department of Neurosurgery, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Brain Res. 1989 Oct 16;499(2):367-70. doi: 10.1016/0006-8993(89)90786-5.

Uric acid (UA) in the rat brain was measured by HPLC with an electrochemical detector following focal ischemia. At 24 h after the operation, the UA level in the ischemic center was 105.47 +/- 8.39 nmol/g tissue, whereas it was 8.36 +/- 1.86 in the sham-operated group. Allopurinol, xanthine oxidase inhibitor, almost completely inhibited this UA accumulation. These data demonstrate that the UA increase in the ischemic brain is due to the xanthine oxidase reaction.