局灶性脑缺血后大鼠脑内尿酸水平的变化

Changes of uric acid level in rat brain after focal ischemia.

作者信息

Kanemitsu H, Tamura A, Sano K, Iwamoto T, Yoshiura M, Iriyama K

出版信息

J Neurochem. 1986 Mar;46(3):851-3. doi: 10.1111/j.1471-4159.1986.tb13049.x.

DOI:10.1111/j.1471-4159.1986.tb13049.x

Abstract

Changes of uric acid level in rat cerebral hemisphere after left middle cerebral artery (MCA) occlusion were studied by reversed-phase HPLC with electrochemical detection. Uric acid level in the normal group was 2.98 nmol/g tissue. Uric acid concentration of the left hemisphere in the left MCA-occluded group progressively increased after occlusion, and reached a maximum value of 67.26 nmol/g tissue 24 h after ischemia. Uric acid levels in the right hemisphere remained unchanged. Uric acid concentration of the left hemisphere in sham-operated group was 9.29 nmol/g tissue 24 h after the operation.

摘要

采用反相高效液相色谱电化学检测法，研究大鼠大脑中动脉（MCA）左侧闭塞后大脑半球尿酸水平的变化。正常组尿酸水平为2.98 nmol/g组织。左侧大脑中动脉闭塞组左侧半球尿酸浓度在闭塞后逐渐升高，缺血24小时后达到最大值67.26 nmol/g组织。右侧半球尿酸水平无变化。假手术组术后24小时左侧半球尿酸浓度为9.29 nmol/g组织。