Antibodies in serum of patients with Alzheimer's disease cause immunolysis of cholinergic nerve terminals from the rat cerebral cortex.
作者信息
Bradford H F, Foley P, Docherty M, Fillit H, Luine V N, McEwen B, Bucht G, Winbald B, Hardy J
机构信息
Department of Biochemistry, Imperial College of Science and Technology, London, UK.
出版信息
Can J Neurol Sci. 1989 Nov;16(4 Suppl):528-34. doi: 10.1017/s0317167100029875.
PMID:2804815
Abstract
A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
摘要
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