Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.
作者信息
Foley P, Bradford H F, Docherty M, Fillit H, Luine V N, McEwen B, Bucht G, Winblad B, Hardy J
机构信息
Department of Biochemistry, Imperial College of Science and Technology, London, UK.
出版信息
J Neurol. 1988 Nov;235(8):466-71. doi: 10.1007/BF00314249.
PMID:3210051
Abstract
A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
摘要
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