Bai Chyi-Huey, Chien Yi-Wen, Huang Tzu-Chieh, Wu Shin-Jiuan, Yeh Nai-Hua, Pan Wen-Harn, Chang Jung-Su
Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan, ROC.
Asia Pac J Clin Nutr. 2017 Jan;26(1):78-84. doi: 10.6133/apjcn.102015.09.
Alanine aminotransferase (ALT) is generally used for evaluating liver function, and its concentrations are closely associated with sex and nutritional status. This study investigates the relationships between dietary components and serum ALT activity in Taiwanese adolescents.
Data were collected from 1,941 adolescents aged 13-18 years who participated in the fourth National Nutrition and Health Survey in Taiwan (2010-2011, adolescents).
The mean age was 15.3±0.1 y (15.3±0.1 y for boys and 15.2±0.1 y for girls). Mean serum ALT was 14.8±13.3 U/L (17.7±16.3 U/L for boys and 12.1±8.7 U/L for girls; p<0.001). Multivariate analysis revealed that, among girls, a single-unit increase in dietary zinc was associated with 1.12- and 1.11-fold increases in risk for increased serum ALT tertile 2 (T2) and T3, respectively, compared with T1; and a single-unit increase in vitamin B-2 intake increased risk by 1.71- and 1.54-fold, respectively. Further analysis revealed that the risk increase for boys and girls who consumed the highest amounts of dietary zinc and vitamin B-2 (T3) was 1.97- and 2.62-fold, respectively; they were also more likely to have higher serum ALT (>11 U/L for boys and >9 U/L for girls) than those of the reference (presented as zinc T1 and vitamin B-1 T1).
Increased dietary zinc and vitamin B-2 intake is associated with higher serum ALT in adolescents.
丙氨酸转氨酶（ALT）通常用于评估肝功能，其浓度与性别和营养状况密切相关。本研究调查台湾青少年饮食成分与血清ALT活性之间的关系。
数据收集自1941名13 - 18岁参与台湾第四次全国营养与健康调查（2010 - 2011年，青少年）的青少年。
平均年龄为15.3±0.1岁（男孩为15.3±0.1岁，女孩为15.2±0.1岁）。平均血清ALT为14.8±13.3 U/L（男孩为17.7±16.3 U/L，女孩为12.1±8.7 U/L；p<0.001）。多变量分析显示，在女孩中，饮食锌每增加一个单位，血清ALT处于第二三分位数（T2）和第三三分位数（T3）的风险分别比处于第一三分位数（T1）增加1.12倍和1.11倍；维生素B - 2摄入量每增加一个单位，风险分别增加1.71倍和1.54倍。进一步分析显示，饮食锌和维生素B - 2摄入量最高（T3）的男孩和女孩，风险增加分别为1.97倍和2.62倍；与参考组（锌T1和维生素B - 1 T1）相比，他们血清ALT水平较高（男孩>11 U/L，女孩>9 U/L）的可能性也更大。
青少年饮食中锌和维生素B - 2摄入量增加与血清ALT升高有关。
