Kara Murat, Ekiz Timur, Kara Özgür, Tiftik Tülay, Malas Fevziye Ünsal, Özbudak Demir Sibel, Özgirgin Neşe
Hacettepe University Medical School, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.
Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey. Email:
Asia Pac J Clin Nutr. 2017 Jan;26(1):85-88. doi: 10.6133/apjcn.102015.12.
The objective of this study was to explore the association between 25- hydroxyvitamin D (25(OH)D) and muscle strength/architecture.
Thirty patients (27 women, 3 men) were allocated into Group I (n=15, mean age; 44.4±9.4 years) and Group II (n=15, mean age; 39.0±9.9 years) according to the median of 25(OH)D (<13.7 ng/mL vs >13.7 ng/mL, respectively). Peak torque/body weight of the knee flexor/extensor muscles at 60°/sec and 180°/sec and those of ankle flexor/ extensor muscles at 30°/sec and 90°/sec were evaluated by using a Biodex System 3 Pro Multijoint System isokinetic dynamometer. A 7-12 MHz linear array probe was used to evaluate thickness (MT), pennation angle (PA) and fascicle length (FL) of medial gastrocnemius and vastus lateralis muscles.
Mean of 25(OH)D was 9.4±2.5 ng/mL and 20.7±8.3 ng/mL in Groups I and II, respectively. Although all isokinetic strength parameters were lower in Group I, significant differences were found in knee flexion at 180°/sec (p=0.007), knee extension at 30°/sec (p=0.038) and 180°/sec (p=0.001), and ankle extension at 30°/sec (p=0.002) and 90°/sec (p=0.007). On the other hand, no significant difference was found between the groups regarding MT, PA and FL values (all p>0.05).
In light of our results, we can argue that 25(OH)D is associated with muscle strength but not with muscle architecture. Further studies concerning the long-term follow-up effects of 25(OH)D treatment on muscle strength are awaited.
本研究的目的是探讨25-羟基维生素D（25(OH)D）与肌肉力量/结构之间的关联。
根据25(OH)D的中位数（分别为<13.7 ng/mL和>13.7 ng/mL），将30例患者（27名女性，3名男性）分为I组（n = 15，平均年龄44.4±9.4岁）和II组（n = 15，平均年龄39.0±9.9岁）。使用Biodex System 3 Pro多关节系统等速测力计评估膝关节屈肌/伸肌在60°/秒和180°/秒以及踝关节屈肌/伸肌在30°/秒和90°/秒时的峰值扭矩/体重。使用7-12 MHz线性阵列探头评估腓肠肌内侧头和股外侧肌的厚度（MT）、羽状角（PA）和肌束长度（FL）。
I组和II组的25(OH)D均值分别为9.4±2.5 ng/mL和20.7±8.3 ng/mL。虽然I组的所有等速力量参数均较低，但在180°/秒的膝关节屈曲（p = 0.007）、30°/秒（p = 0.038）和180°/秒（p = 0.001）的膝关节伸展以及30°/秒（p = 0.002）和90°/秒（p = 0.007）的踝关节伸展方面发现了显著差异。另一方面，两组在MT、PA和FL值方面未发现显著差异（所有p>0.05）。
根据我们的结果，我们可以认为25(OH)D与肌肉力量相关，但与肌肉结构无关。期待有关25(OH)D治疗对肌肉力量的长期随访效果的进一步研究。
