Messing E M, Young T B, Hunt V B, Wehbie J M, Rust P
Department of Surgery and Human Oncology, University of Wisconsin School of Medicine, Madison.
Cancer. 1989 Dec 1;64(11):2361-7. doi: 10.1002/1097-0142(19891201)64:11<2361::aid-cncr2820641128>3.0.co;2-4.
In a homescreening study 235 asymptomatic men, 50 years of age and older without known causes of hematuria, tested their urine each week with a chemical reagent strip for the presence of blood for 1 year. Forty-four men had hematuria at least once, and 31 had a full urologic evaluation. Of these, eight were found to have urinary cancers and seven had nonmalignant diseases warranting immediate treatment. In six of these 15 men (only two with cancer) hematuria occurred in over 1/3 of the testings, and in four hematuria was found on microscopic urinalysis at the time of urologic evaluation. The degree of hematuria was unrelated to the seriousness of its cause. We conclude that in this population hematuria occurs intermittently and when found, regardless of quantity or symptoms, serious underlying pathology must be ruled out. Furthermore, regular hematuria home testing offers a promising means of detecting urinary cancers and other diseases that warrant therapy in asymptomatic men 50 years of age and older.
在一项家庭筛查研究中，235名50岁及以上无血尿已知病因的无症状男性，每周使用化学试剂条检测尿液中的血液情况，持续1年。44名男性至少有一次血尿，31名接受了全面的泌尿科评估。其中，8人被发现患有泌尿癌症，7人患有需要立即治疗的非恶性疾病。在这15名男性中的6人（仅2名癌症患者），超过三分之一的检测出现血尿，4人在泌尿科评估时通过显微镜尿检发现血尿。血尿程度与其病因的严重性无关。我们得出结论，在该人群中血尿呈间歇性出现，一旦发现，无论出血量或症状如何，都必须排除严重的潜在病理情况。此外，定期进行家庭血尿检测为检测50岁及以上无症状男性的泌尿癌症和其他需要治疗的疾病提供了一种有前景的方法。
