Watanabe Rei
Department of Dermatology, Faculty of Medicine, University of Tsukuba.
Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(6):505-512. doi: 10.2177/jsci.39.505.
Recent researches are revealing the importance of a new subset of memory T cells called resident memory T cells (T). Once they enter the tissues according to their tissue-homing receptors, TRMs do not go back to circulation and stay in the same tissues for a long time. These T cells are defined as expressing CD69 and/or CD103, and are known to show strong effector functions. It is considered that T have an important role against infection in barrier tissues such as GI tract, skin, respiratory system and reproductive tract. Furthermore, recent reports indicate their roles in organ-specific chronic inflammatory disorders, autoimmune disorders and tumor immunology even in non-barrier tissues such as central nerve system, lymphatic tissue, liver, kidney, pancreas and joint. Here in this session, the author organized what have been known about T both in mouse and human, including the development, functional activities and relation of T to disease manifestation, for the detailed understanding of this fraction.
近期研究揭示了一种名为组织驻留记忆T细胞（TRM）的新型记忆T细胞亚群的重要性。一旦它们根据其组织归巢受体进入组织，TRM就不会再回到循环中，并在同一组织中长时间停留。这些T细胞被定义为表达CD69和/或CD103，并且已知具有强大的效应功能。人们认为TRM在抵御胃肠道、皮肤、呼吸系统和生殖道等屏障组织中的感染方面具有重要作用。此外，最近的报告表明，即使在中枢神经系统、淋巴组织、肝脏、肾脏、胰腺和关节等非屏障组织中，它们在器官特异性慢性炎症性疾病、自身免疫性疾病和肿瘤免疫学中也发挥着作用。在本次会议中，作者整理了关于小鼠和人类TRM的已知信息，包括其发育、功能活动以及TRM与疾病表现的关系，以便更详细地了解这一细胞组分。
