Nishioka Kenya, Fujimaki Motoki, Kanai Kazuaki, Ishiguro Yuta, Nakazato Tomoko, Tanaka Ryota, Yokoyama Kazumasa, Hattori Nobutaka
Department of Neurology, Juntendo University School of Medicine, Japan.
Intern Med. 2017;56(1):101-104. doi: 10.2169/internalmedicine.56.7578. Epub 2017 Jan 1.
Renal cell carcinoma (RCC) patients who develop a paraneoplastic syndrome may present with neuromuscular disorders. We herein report the case of a 50-year-old man who suffered from progressive gait disturbance and muscle weakness. The results of a nerve conduction study fulfilled the criteria of chronic inflammatory demyelinating polyneuropathy. An abdominal CT scan detected RCC, the pathological diagnosis of which was clear cell type. After tumor resection and a single course of intravenous immunoglobulin therapy, the patient's symptoms drastically improved over the course of one year. The patient's neurological symptoms preceded the detection of cancer. A proper diagnosis and the initiation of suitable therapies resulted in a favorable outcome.
发生副肿瘤综合征的肾细胞癌（RCC）患者可能会出现神经肌肉疾病。我们在此报告一例50岁男性患者，他患有进行性步态障碍和肌肉无力。神经传导研究结果符合慢性炎症性脱髓鞘性多发性神经病的标准。腹部CT扫描检测到肾细胞癌，病理诊断为透明细胞型。经过肿瘤切除和一个疗程的静脉注射免疫球蛋白治疗后，患者的症状在一年内大幅改善。患者的神经症状先于癌症的发现。正确的诊断和适当治疗的启动带来了良好的结果。
