与枸橼酸莫沙必利相关的药物性肝损伤：两例报告
Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases.
作者信息
Sako Ayaka, Bae Sung Kwan, Gushima Toshifumi, Motoshita Junichi, Bekki Shigemune, Abiru Seigo, Komori Atsumasa, Shimoda Shinji, Ito Masahiro, Yatsuhashi Hiroshi, Takahashi Kazuhiro
机构信息
The Center for Liver Disease, Hamanomachi Hospital, Japan.
出版信息
Intern Med. 2017;56(1):41-45. doi: 10.2169/internalmedicine.56.7374. Epub 2017 Jan 1.
We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was "highly probable".
我们在此报告两例因莫沙必利导致的药物性肝损伤（DILI）病例。病例1：一名78岁男性因转氨酶水平升高入院。停用莫沙必利后，肝酶水平升高的情况得到改善。病例2：一名54岁男性因黄疸入院。立即停用莫沙必利，并给予甲泼尼龙治疗急性肝衰竭。患者的数据显示有所改善，于第32天出院。在这两例病例中，莫沙必利对药物诱导淋巴细胞刺激试验（DLST）呈阳性反应，并且根据药物性肝损伤标准得出的患者评分“很可能”为药物性肝损伤。
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