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与10型肺炎克雷伯菌K抗原相关的二糖和三糖的合成及其在沉淀素反应中的抑制作用研究。

Synthesis of a di- and a tri-saccharide related to the K-antigen of Klebsiella type 10 and a study of their inhibition in the precipitin reaction.

作者信息

Sarkar A K, Ray A K, Roy N

机构信息

Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta.

出版信息

Carbohydr Res. 1989 Jul 15;190(2):181-9. doi: 10.1016/0008-6215(89)84124-2.

DOI:10.1016/0008-6215(89)84124-2
PMID:2805007
Abstract

Syntheses of methyl 3-O-alpha-D-galactopyranosyl-alpha-D-mannopyranoside (10) and methyl 3-O-alpha-D-galactopyranosyl-2-O-(beta-D-glucopyranosyluronic acid)-alpha-D-mannopyranoside (11) in good yield are described. Both 10 and 11 significantly inhibit antigen-antibody precipitation in the Klebsiella Type 10 immune system. The results provide more evidence for the structure (1) of the antigen from Klebsiella K-10 and its immunodominant grouping.

摘要

已描述了以良好产率合成3 - O-α-D-吡喃半乳糖基-α-D-甘露吡喃糖苷甲酯（10）和3 - O-α-D-吡喃半乳糖基-2 - O-（β-D-吡喃葡萄糖醛酸）-α-D-甘露吡喃糖苷甲酯（11）的方法。10和11均能显著抑制10型克雷伯菌免疫系统中的抗原-抗体沉淀。这些结果为来自克雷伯菌K-10的抗原结构（1）及其免疫显性分组提供了更多证据。

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