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与肺炎克雷伯菌40型多糖相关的二糖甲基糖苷的合成及其在沉淀素反应中抑制作用的研究

Synthesis of disaccharide methyl glycosides related to the polysaccharide from Klebsiella serotype 40 and a study of their inhibition in the precipitin reaction.

作者信息

Maddali U B, Ray A K, Roy N

机构信息

Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta.

出版信息

Carbohydr Res. 1990 Dec 15;208:59-66. doi: 10.1016/0008-6215(90)80085-h.

DOI:10.1016/0008-6215(90)80085-h
PMID:2085817
Abstract

The methyl glycosides of alpha-D-Manp-(1----4)-alpha-L-Rhap (3), alpha-L-Rhap-(1----3)-beta-D-Galp (4), beta-L-Rhap-(1----3)-beta-D-Galp (5), beta-D-Galp-(1----2)-alpha-L-Rhap (6), and beta-D-GlcpA-(1----2)-alpha-L-Rhap (7) have been synthesised and their inhibition reactions in the Klebsiella serotype 40 immune system have been studied. The results obtained accord with only one of two structures proposed for the repeating unit of the K40 antigen.

摘要

已合成了α-D-甘露糖基-(1→4)-α-L-鼠李糖(3)、α-L-鼠李糖基-(1→3)-β-D-半乳糖(4)、β-L-鼠李糖基-(1→3)-β-D-半乳糖(5)、β-D-半乳糖基-(1→2)-α-L-鼠李糖(6)和β-D-葡萄糖醛酸基-(1→2)-α-L-鼠李糖(7)的甲基糖苷,并研究了它们在肺炎克雷伯菌40型免疫系统中的抑制反应。所得结果仅与为K40抗原重复单元提出的两种结构之一相符。

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