Girardi Fábio Muradás
Department of Head and Neck Surgery, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, Brazil.
Int Arch Otorhinolaryngol. 2017 Jan;21(1):38-41. doi: 10.1055/s-0036-1585095. Epub 2016 Jul 12.
Patients with thyroid cancer in different age groups present with different prognosis. The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. This is a retrospective study. From 2000 to 2010, 623 patients underwent thyroidectomy for cancer in our institution, with 596 enrolled. Patients were divided into groups of 10 years and then in four age subgroups (≤ 24, 25-44, 45-64, and ≥65 years) for statistical analysis. We compared age, gender, and histopathological characteristics between groups. Individuals belonging to the earlier age group presented with a highest prevalence of neuro-vascular invasion, capsular invasion and lymph node metastasis. Together with individuals of advanced age, that group also had larger tumor diameter and higher prevalence of extra-glandular disease. Even when analyzed only cases with well-differentiated carcinoma, younger individuals remain with a highest prevalence of lymph node metastasis, neuro-vascular invasion and larger tumor diameter. We observed a distinct pattern of clinicopathological manifestation of thyroid cancer according to age. Individuals belonging to age extremes resemble in several pathological features, and young people usually present with more aggressive disease characteristics.
不同年龄组的甲状腺癌患者预后不同。本研究的目的是分析不同年龄组甲状腺癌的临床病理特征。这是一项回顾性研究。2000年至2010年，我院623例患者因癌症接受甲状腺切除术，其中596例纳入研究。患者按10年分组，然后分为四个年龄亚组（≤24岁、25 - 44岁、45 - 64岁和≥65岁）进行统计分析。我们比较了各组之间的年龄、性别和组织病理学特征。年龄较小的组神经血管侵犯、包膜侵犯和淋巴结转移的发生率最高。该组与老年患者一样，肿瘤直径也较大，腺外疾病的发生率也较高。即使仅分析高分化癌病例，年轻患者的淋巴结转移、神经血管侵犯发生率和肿瘤直径仍最高。我们观察到甲状腺癌的临床病理表现因年龄而异。年龄两端的患者在一些病理特征上相似，而年轻人通常表现出更具侵袭性的疾病特征。
