Goyal Abhinav, Chatterjee Kshitij, Shah Nishi, Singh Shailender
Abhinav Goyal, Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA 19141, United States.
World J Hepatol. 2016 Dec 18;8(35):1564-1568. doi: 10.4254/wjh.v8.i35.1564.
To determine the association between cirrhosis and ischemic stroke in a large nationally representative sample.
A retrospective cross-sectional study of all hospitalized patients during 2012 and 2013 in the United States was performed using the National Inpatient Sample database. Hospitalizations with acute stroke, cirrhosis and other risk factors were identified using ICD-9-CM codes.
There were a total of 72082638 hospitalizations in the United States during the years 2012 and 2013. After excluding hospitalizations with missing demographic variables, that there were a total of 1175210 (1.6%) out of these were for acute ischemic stroke. Cirrhosis was present among 5605 (0.4%) cases of ischemic stroke. Mean age among the cirrhotic and non-cirrhotic groups with ischemic stroke were 66.4 and 70.5 years, respectively. Prevalence of risk factors among the two groups was also calculated. After adjusting for various known risk factors the odds of having an ischemic stroke (OR = 0.28, < 0.001) were 72% lower in cirrhotics compared to non-cirrhotics.
Our study suggests that in a large, nationally representative sample of the United States population, cirrhosis is associated with a lower likelihood of stroke.
在一个具有全国代表性的大样本中确定肝硬化与缺血性卒中之间的关联。
利用美国国家住院样本数据库对2012年和2013年期间所有住院患者进行回顾性横断面研究。使用ICD-9-CM编码识别急性卒中、肝硬化及其他危险因素的住院病例。
2012年和2013年美国共有72082638例住院病例。在排除人口统计学变量缺失的住院病例后，其中共有1175210例（1.6%）为急性缺血性卒中。5605例（0.4%）缺血性卒中病例存在肝硬化。肝硬化组和非肝硬化组缺血性卒中患者的平均年龄分别为66.4岁和70.5岁。还计算了两组危险因素的患病率。在对各种已知危险因素进行校正后，肝硬化患者发生缺血性卒中的几率（OR = 0.28，< 0.001）比非肝硬化患者低72%。
我们的研究表明在美国一个具有全国代表性的大样本人群中，肝硬化与卒中发生可能性较低相关。
